IndraLab

Statements

Atorvastatin inhibits MYD88. 4 / 4
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"Moreover, atorvastatin markedly inhibited the upregulation of toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88), which indicated deactivation of NLRP3 inflammasomes."
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"In conclusion, Pre-CIH atorvastatin administration may attenuate TLR-4 and MYD88 mediated inflammatory processes and oxidative stress in the injured rat myocardium, and this may be one mechanism by which atorvastatin ameliorated myocardial injury following CIH."
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"Furthermore, atorvastatin also inhibited the expression of TLR4/MyD88/NF-κB pathway-related proteins (TLR4, MyD88, and p-NF-κB p65)."
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"Atorvastatin decreased the neural injury and the elevation of TLR4, MyD88, TRIF, pro inflammatory cytokines and oxidative stress caused by CIH."
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