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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNH5 inhibits MB. 2 / 2

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"We provide evidence that the known EAG2 channel blocker astemizole reduces MB cell migratory polarization and cell rear contraction, and impairs MB cell viability, motility and allografted tumor growth (XREF_FIG and XREF_SUPPLEMENTARY)."

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"The ability of two structurally unrelated EAG2 channel blockers to reduce MB growth in vivo in mouse models, taken together with the specific effects of thioridazine in curbing the growth and metastasis of xenograft human MB with high but not low EAG2 expression, point to EAG2 as a promising target for treatment of MB that displays high EAG2 expression."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...