IndraLab

Statements

Protease activates ZUP1. 5 / 5
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reach
"Further studies are needed to determine if these inhibitors can be developed into clinically useful antiviral agents.Analysis of SARS-CoV papain-like protease led to the surprising discovery that this protease is also a viral deubiquitinating (DUB) enzyme."
| PMC
eidos
"These findings lead us to an intriguing alternative hypothesis , that protease inhibitors reduce the levels / activity of the DUBs that target these viral oncoproteins , thereby causing increased ubiquitination of E6 and E7 , and consequently increased degradation ."
33668328
eidos
"Furthermore , addition of a protease inhibitor that blocks both protease and DUB activity [ 52 ] failed to abrogate the PLP inhibition on activation of IRF-3 dependent promoters [ 14 ] ."
22312431
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"For the distantly related arterivirus EAV, infection with a mutant lacking a similar papain-like protease-driven DUB activity resulted in an increased innate immune response after infection, indicating that the viral DUB activity indeed has a function in suppression of innate immune response during infection (van Kasteren et al. 2013)."
28643204
reach
"Further studies are needed to determine if these inhibitors can be developed into clinically useful antiviral agents.Analysis of SARS-CoV papain-like protease led to the surprising discovery that this protease is also a viral deubiquitinating (DUB) enzyme."
| PMC