IndraLab

Statements

Mutated KRAS activates angiogenesis. 5 / 5
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"It is supposed that the KRAS mutation might activate angiogenesis in several ways : by increasing production of VEGF and CXCL-8 (proangiogenetic interleukin 8) and by activating growth of the tumour cells (30, 31)."
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"Activating KRAS mutation in carcinoma cells may induce angiogenesis via several mechanisms."
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"Kras mutation can induce proliferation of tumor cell, angiogenesis and some adverse events such as invasion or metastasis."
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"Previous research has shown that KRAS mutations support the production of VEGF and the decline of angiogenesis inhibitor thrombospondin."
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"ADS and EC share several altered molecular pathways, such as high level of vascular endothelial growth factor, platelet-derived growth factor, increased production of reactive species of oxygen and pro-inflammatory cytokines, KRAS mutations [31], which lead to increased angiogenesis, abnormal tissue growth, and invasion [32]."
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