IndraLab

Statements

EGF phosphorylates EGFR on Y869. 24 / 24
| 13 11
reach
"We found that MUC20 overexpression increased EGF triggered phosphorylation of EGFR and Y845, EGFR and Y1068, Src, and STAT3."
23262208
reach
"In contrast, EGF does not induce accumulation of EGFR phosphorylated at Tyr 845."
19766894
sparser
"In accordance, EGF stimulated the phosphorylation of EGFR at Y845, a known Src-phosphorylation site xref , in AAC-19, but not in Y260A mutant cells."
30120256
reach
"Whereas EGF treatment caused the phosphorylation of EGFR at tyr 845, treatment with Cd did not (XREF_FIG)."
26006730
reach
"TSP1 and its EGF like repeats also increased phosphorylation of EGFR Tyr 845, Tyr 992, Tyr 1045, Tyr 1086, and Tyr 1173, activated phospholipase Cgamma, and increased cell migration."
19129184
reach
"XREF_FIG, EGF activated phosphorylation of EGFR at the sites of tyrosine 845 (pEGFR845), 992 (pEGFR992) and 1068 (pEGFR1068) in vitro."
31952541
sparser
"EGF induced phosphorylation of EGFR at Tyr residue 845 was higly reduced by c-SRC inhibitor PP1."
27564112
reach
"In accordance, EGF stimulated the phosphorylation of EGFR at Y845, a known Src-phosphorylation site , in AAC-19, but not in Y260A mutant cells."
30120256
sparser
"Our data showed that B4GALNT3 knockdown suppressed EGF-induced phosphorylation of EGFR at Y845 and Y1068 (Figure xref )."
25003232
reach
"In addition, the phosphorylation of Y845 on EGFR by EGF, which is mediated through c-Src or related kinases but not autophosphorylation, was also affected by MNNG."
15708576
sparser
"However, in HER2-expressing cells, EGF only modestly increased the high basal P-HER2 and EGFR phosphorylation at Y1068 and Y845 (B)."
16843263
reach
"EGF stimulation of the resulting lines induced EGFR phosphorylation on Tyr 845 in the EGFR overexpressing lines."
27495374
sparser
"We observed a decrease in EGF-induced EGFR phosphorylation at Tyr-845 and/or Tyr-1068 residue(s) in the presence of AnxA2 antibody, suggesting that AnxA2 regulates the overall function of EGFR, leading to the inhibition of cancer cell proliferation and migration."
25321192
sparser
"In contrast, EGF induced phosphorylation of Tyr845 of EGFR and Tyr1112 of ErbB2 ( xref )."
34025398
reach
"Here, we showed that GALNT2 modifies O-glycans on EGFR and enhances EGF triggered phosphorylation of EGFR at both Y1068 and Y845 in OSCC."
24582885
sparser
"In contrast, galardin did not inhibit EGF-induced EGFR Tyr-845 and Tyr-1068 phosphorylation ( Fig. 2 inserts), indicating that MMP-mediated phosphorylation of these sites is specific to GPCR signalin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14568001
sparser
"In addition, the phosphorylation of Y845 on EGFR by EGF, which is mediated through c-Src or related kinases but not autophosphorylation, was also affected by MNNG."
15708576
sparser
"Moreover, EGFR phosphorylation at Y1173 and Y845 was induced by EGF but not by four different PV-IgG fractions."
31178865
reach
"In this study, overexpression of MUC20 increased EGF triggered phosphorylation of EGFR at Y845 and Y1068 and also enhanced phosphorylation of STAT3, but not ERK1/2 and AKT."
23262208
reach
"However, in HER2 YVMA -expressing cells, EGF only modestly increased the high basal P-HER2 and EGFR phosphorylation at Y1068 and Y845."
16843263
reach
"As expected, EGF stimulated EGFR Y845 phosphorylation in response to growth factor addition (XREF_FIG)."
20953304
sparser
"As expected, EGF stimulated EGFR Y845 phosphorylation in response to growth factor addition ( xref )."
20953304
sparser
"In contrast, blockade or silencing of Src only suppressed EGF-induced EGFR phosphorylation at Y845 but did not affect EGFR autophosphorylation at Y1068 by EGF, indicating that ligand-dependent EGFR phosphorylation at Y845 depends on Src whereas autophosphorylation at other residues such as Y1068 is Src-independent."
23349873
reach
"Whereas EGF treatment caused the phosphorylation of EGFR at tyr 845, treatment with Cd did not."
26006730