IndraLab

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FOXO6 activates USP7. 11 / 11
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"XREF_BIBR Current experimental data showed that JMJD3 overexpression reduced the accumulation of EZH2 in the CLU promoter region, indicating that FOXO6 was able to mediate USP7 to regulate the stability of JMJD3, which is a competitor for EZH2 in binding with the promoter region of CLU, the downstream target gene, and then participate in regulating the tumorigenesis and development of EC."
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"The above evidence revealed that FOXO6 upregulated the expression of USP7 in EC to inhibit the apoptosis of tumor cells and promote their proliferation ."
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"Silencing of FOXO6 physically reduced USP7, resulting in promoted EC apoptosis."
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"A previous study XREF_BIBR showed that USP7 transcriptional activation by FOXO6 suppresses lung cancer progression and that USP7 inhibited cell proliferation in EC."
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"In addition , FOXO6 knockdown suppressed the expression of USP7 and that of apoptosis-related protein c-CASP3 ."
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"61 FoxO6 is downregulated in lung adenocarcinoma, and FoxO6 overexpression upregulates HAUSP and consequently facilitates p53 stabilization."
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"To verify whether FOXO6 promoted the progression of EC through JMJD3 and CLU by mediating USP7, we first constructed FOXO6 overexpression cell lines combined with or without si-USP7 plasmid."
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"Collectively , these data indicated that deficiency of FOXO6 transcriptionally deregulated expression of USP7 and induced USP7-mediated apoptosis ."
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"XREF_BIBR We hypothesized that FOXO6 initiates the activation of USP7 in EC."
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"A previous study xref showed that USP7 transcriptional activation by FOXO6 suppresses lung cancer progression and that USP7 inhibited cell proliferation in EC. xref We hypothesized that FOXO6 initiates the activation of USP7 in EC."
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"FOXO6 promoted USP7 expression , which enhanced JMJD3 ubiquitination and promoted CLU expression ."
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