Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EGFR-L858R activates AKT. 2 / 2

| 2

➶

reach

"EGFR L858R and PIK3CA H1047R, which preferentially activated Akt, did not stimulate changes in the expression or H3K27ac levels at Spry124 -/- target genes."

26279576

➶

reach

"Oncogenic EGFR L858R and PIK3CA H1047R potently activated Akt but did not induce changes in the expression or chromatin marking at enhancers of Spry124 -/- target genes, suggesting that EGFR L858R and PIK3CA H1047R regulate distinct subsets of genes and enhancers."

26279576

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...