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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 bound to TP53 increases the amount of TP53. 2 / 2

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"The p53 level and activity are mainly mediated by ubiquitin E3 ligase Mdm2, which binds directly to p53 and facilitates p53 ubiquitination and proteasomal degradation [XREF_BIBR]."

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"It has been reported that the level and activity of p53 are strictly modulated by the ubiquitin E3 ligase Mdm2, which binds p53 directly and mediates p53 ubiquitination and proteasomal degradation continuously (21)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...