IndraLab

Statements

Phosphorylated IRS1 leads to the phosphorylation of AKT1. 2 / 2
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"The downregulation of insulin response under oxidant exposure involves activation of tumor necrosis factor-alpha; increased Ser/Thr phosphorylation of insulin receptor and insulin receptor substrate-1 (IRS1) reduces the redistribution of IRS1 and phosphatidylinositol 3 kinase from the cytosolic to microsomal fraction, reduces protein kinase-B (Akt) phosphorylation, and results in decreased trafficking of GLUT4 to the plasma membrane."
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"These serine kinases suppress insulin receptor substrate 1 (IRS1) phosphorylation, thereby inhibiting downstream phosphorylation of protein kinase B (Akt) (10–12)."
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