A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

Phosphorylated IRS1 leads to the phosphorylation of AKT1. 1 / 1
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"The downregulation of insulin response under oxidant exposure involves activation of tumor necrosis factor-alpha; increased Ser/Thr phosphorylation of insulin receptor and insulin receptor substrate-1 (IRS1) reduces the redistribution of IRS1 and phosphatidylinositol 3 kinase from the cytosolic to microsomal fraction, reduces protein kinase-B (Akt) phosphorylation, and results in decreased trafficking of GLUT4 to the plasma membrane."