Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Phosphorylated IRS1 leads to the phosphorylation of AKT1. 1 / 1

| 1

➶

reach

"The downregulation of insulin response under oxidant exposure involves activation of tumor necrosis factor-alpha; increased Ser/Thr phosphorylation of insulin receptor and insulin receptor substrate-1 (IRS1) reduces the redistribution of IRS1 and phosphatidylinositol 3 kinase from the cytosolic to microsomal fraction, reduces protein kinase-B (Akt) phosphorylation, and results in decreased trafficking of GLUT4 to the plasma membrane."

20007934

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...