IndraLab

Statements

Celastrol inhibits NLRP3. 3 / 3
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"Notably, interruption of ASC oligomerization and autophagy activation are involved in NLRP3 inflammasome inactivation by celastrol."
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"Importantly, we observed that pretreatment of 3-MA enhanced IL-1β production and reversed celastrol-induced NLRP3 inflammasome inhibition ( xref , Figure xref and xref )."
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"Intriguingly, 3-MA treatment could impair celastrol-induced NLRP3 inflammasome inhibition (Figure xref ), indicating that autophagy plays a critical role in celastrol-induced NLRP3 inflammasome inhibition in systemic inflammation."
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