IndraLab
Statements
sparser
"However, we reported that in addition to GRK2 and Raf-1 binding to PEBP1, the eicosanoid generating enzyme, 15LO1, also binds PEBP1. xref 15LO1, a lipoxygenase that generates 15 hydroxyeicosatetraenoic acid (15s-HETE), is upregulated in response to IL-13 stimulation of HAECs and is increased in asthma in relation to Type-2/eosinophilic processes. xref xref – xref , xref In addition to upregulation of 15LO1 in response to IL-13, stimulation of HAECs with IL-13 promotes binding of 15LO1 to PEBP1, with subsequent release of Raf-1, activation of ERK and increased expression of the airway mucin, MUC5AC. xref Thus, we hypothesized that in the presence of IL-13, 15LO1 would compete with GRK2 for binding to PEBP1, leading to more free GRK2 and greater likelihood for β2AR desensitization (even in the absence of β2 stimulation)."