IndraLab

Statements

USP9X inhibits Neoplasms. 4 / 5
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"USP9X elicited tumor suppressor role by preventing degradation of EGLN3 ."
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"In a mouse xenograft model of triple negative breast cancer (negative for the estrogen, progesterone, and HER2 receptors), the FAF/Rapa formulation potently inhibited tumor growth and exhibited a better toxicity profile compared to free Rapa control."
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"The pharmacological inhibition of USP9x using G9, a partially selective, small-molecule USP9x inhibitor, reduced Notch activity, remodeled the tumor immune landscape, and reduced tumor growth without associated toxicity."
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"Furthermore, the expression level of USP9X is positively related to LATS expression but negatively associated with the expression of YAP/TAZ in multiple tumor tissues, such as pancreatic cancer and breast cancer, demonstrating that USP9X potentiates LATS kinase in suppressing tumor growth (Toloczko et al., 2017)."
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