IndraLab

Statements

Nitric oxide decreases the amount of USP5. 4 / 5
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"We provide evidence that, although administration of NO in vitro had no effect on isopeptidase T levels or intracellular localization in VSMC, external administration of NO in vivo in a carotid artery model of neointimal hyperplasia decreased isopeptidase T levels, while increasing levels of ubiquitinated proteins."
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"Although NO decreased the overall levels of isopeptidase T throughout the arterial wall at both time points after injury, the most prominent decrease was seen at 14 days."
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"Finally, we show that periadventitial administration of NO decreases levels of isopeptidase T in an animal model of neointimal hyperplasia, which correlates with increased ubiquitinated protein levels."
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"Isopeptidase T was located mostly in the cytoplasm (XREF_FIG), and addition of NO did not affect intracellular localization of isopeptidase T. NO decreases isopeptidase T levels in vivo."
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