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CNTN2 leads to the phosphorylation of CYLD. 4 / 4
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"Based on these prior reports and the data obtained thus far with the MT4 cells, we hypothesized that TAX activation of IKK family of kinases induces the phosphorylation of CYLD to suppress its deubiquitinating activity."
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"We reasoned that since TAX is known to activate IKK and can associate with CYLD , the TAX protein may be sufficient to induce CYLD phosphorylation."
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"Our observations suggest that in cells transformed by HTLV-1, TAX induces the phosphorylation of CYLD to keep it inactive in order to prevent RIPK1 from inducing cell death."
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"Transfection of a TAX-encoding plasmid into HEK293 EBNA cells confirmed that TAX by itself is sufficient to induce CYLD phosphorylation (Fig. 1c)."
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