IndraLab

Statements

USP1 ubiquitinates FANCD2. 9 / 9
| 9
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"USP1 deubiquitinating enzyme activity against purified monoubiquitinated FANCD2 protein could be reconstituted in vitro, demonstrating that UAF1 functions as an activator of USP1."
18687060
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"Since Usp1 depletion resulted in increased monoubiquitination of Fancd2, we examined whether this monoubiquitinated Fancd2 is localized to chromatin by using biochemical cell fractionation (XREF_FIG)."
19217432
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"USP1 ablation increases FANCD2 and PCNA monoubiquitination but unexpectedly results in DNA crosslinker sensitivity."
18082605
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"For example, a USP1 knockout in a FANCC deficient background can reverse the loss of FANCD2 mono-ubiquitination without enhancing post-MMC cell survival [68]."
28552166
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"Depletion of USP1, a deubiquitinating enzyme targeting FANCD2, elevates the level of FANCD2 monoubiquitination."
22219386
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"Remarkably, depletion of OTUB1 restored a pharmacologically disabled DSB response, indicating that targeting the OTUB1-E2 interaction might be an attractive route for the development of agents that bo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21056014
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"Usp1 -/- bone marrow (BM) cells had increased monoubiquitination of Fancd2 and PCNA, as observed in Usp1 -/- MEFs (data not shown)."
19217432
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"Interestingly, in DT40 cells, double inactivating mutations in FANCC and USP1 restored a quite normal ubiquitination of FANCD2 without restoring the cellular MMC sensitivity but instead aggravating it[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27543315
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"The functions of the Usp1 deubiquitylase (DUB) in the control of genomic stability include the Usp1 mediated deubiquitylation of the monoubiquitylated FancD2, FancI, and PCNA."
23159736