IndraLab

Statements

RPS6KB1-S6K phosphorylates IRS1. 4 / 4
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"P70 S6K also phosphorylates and inhibits insulin receptor substrate-1 (IRS-1), forms a negative feed back regulation of PI3K and Akt signaling."
18790744
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"Importantly, p70 S6K phosphorylates and inhibits IRS-1, resulting in a negative feed back to Akt and mTOR signaling."
18790744
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"ERK, not MTOR and p70 S6K, mediates the phosphorylation of IRS1 in the liver extracts."
19801385
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"We show that in skeletal muscle, adiponectin promotes tyrosine phosphorylation of IRS1 and AKT phosphorylation via inhibiting p70 S6K phosphorylation and serine phosphorylation of IRS1, thereby increasing insulin sensitivity."
26993044