IndraLab

Statements

UCHL5 inhibits Neoplasm Invasiveness. 11 / 11
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"Overexpression of UCH-L5 by Lentivirus infection inhibits migration and invasion of human glioma cells."
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"In vitro analysis revealed that UCHL5 can inhibit migration and invasion of glioma cells mediated via a downregulation of SNRPF [142]."
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"On the other hand, UCH37, the deubiquitinase activated by ADRM1, inhibits glioma cell migration and invasion [42], suggesting that ADRM1 inhibition could have a positive or negative effect on tumor progression, depending on the stage of the tumor.The discovery of a new role for HDAC8 and ADRM1 in MGMT regulation expands the possibilities of the development of new therapies to overcome TMZ resistance in GBM, although several questions about the mechanisms remain to be answered."
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"In vitro, we found that UCH-L5 could inhibit migration and invasion of U87MG and U251 cells."
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"Furthermore, we discovered that UCH-L5 could inhibit cell migration and invasion of glioma cell lines through downregulating SNRPF, a factor of Sm protein ring in the spliceosome."
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"These results suggest that UCH-L5 may inhibit the migration and invasion of glioma cells to inhibit the occurrence of glioma."
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"Furthermore, we found that knockdown of UCH-L5 expression promotes the migration and invasion of U87MG and U251 cells."
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"And overexpression of UCH-L5 inhibits the migration and invasion of U87MG and U251 cells."
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"So UCH-L5 could inhibit glioma cell migration and invasion via downregulating SNRPF."
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"Our study showed that UCH-L5 could inhibit migration and invasion of glioma cells via down regulating expression of SNRPF."
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"Knockdown expression of UCH-L5 by siRNA promotes migration and invasion of human glioma cells."
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