IndraLab

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IL6 leads to the phosphorylation of STAT3 on serine. 11 / 12
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"Serine phosphorylation of Stat3 is also induced by interleukin-6 (IL-6) stimulation, which is shown to be independent of mitogen-activated protein kinase and sensitive to the Ser/Thr kinase inhibitor H7."
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"As shown in Fig. 6 A IL-6 induces STAT3 serine phosphorylation whereas only reduced serine phosphorylation was detectable in SIRP1α-deficient cells.To demonstrate the impact of STAT3 serine phosphoryl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, in contrast to STAT3 activation by growth factors, IL-6 also stimulates STAT3 serine phosphorylation, by an ERK-independent process to enhance trophoblast cells invasion [ 45 ]."
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"In addition to the tyrosine phosphorylation we have observed that IL-6 also induces a serine phosphorylation of STAT3."
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"IL-6 induces the serine phosphorylation of Stat3 transcription factor (Luttiken et al. 1995, Zhang et al. 1995, Pellegrini and Dusanter-Fourt 1997), also known as acute-phase response factor (APRF) (L[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Serine phosphorylation of Stat3, induced by IL-6 stimulation, has been shown to be independent of mitogen activated protein kinase and sensitive to the Ser/Thr kinase inhibitor H7."
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"As shown in Fig. 2C, IL-6 treatment rapidly activates STAT3 serine phosphorylation (lanes 1-5), the peak effect occurring at 30 min and declining towards control levels after longer (120 min) exposure[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We now show that IL-6 triggers a delayed phosphorylation of APRF at serine resudues which can be reversed in vitro by protein phosphatase 2A and is also inhibited by H7."
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"However, in an inflammatory microenvironment, IL-6 is highly expressed by macrophages and potentially triggers STAT3 serine phosphorylation as well as its mitochondrial translocation making it an interesting future target for therapy of inflammatory bone diseases (Li et al., 2022)."
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"Serine phosphorylation of Stat3 is also induced by interleukin-6 (IL-6) stimulation, which is shown to be independent of mitogen activated protein kinase and sensitive to the Ser/Thr kinase inhibitor H7."
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"Interestingly, the cytokine interleukin-6 also stimulates STAT3 serine phosphorylation, but in contrast to growth factors, this occurs by an ERK independent process."
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