IndraLab

Statements

PKA phosphorylates KCND2. 20 / 20
| 4 16
sparser
"Because PKA phosphorylates multiple postsynaptic targets, we wanted to determine whether the direct phosphorylation of Kv4.2 by PKA is the mechanism of Kv4.2 internalization."
18650329
sparser
"One possibility is that Kv4.2 channels are tethered to the plasma membrane by associations with scaffolding proteins, and PKA phosphorylation of Kv4.2 disrupts this association."
18650329
sparser
"Phosphorylation of Kv4.2 by PKA has been shown to induce rapid internalization of the channel protein from the cell surface ( xref , xref , xref )."
26456351
sparser
"We found that while interaction between Kv4.2 and KChIP4a does not require PKA phosphorylation of Kv4.2(S552), phosphorylation of this site is necessary for both enhanced stabilization and membrane expression of Kv4.2 channel complexes produced by KChIP4a."
20045463
reach
"Phosphorylation of Kv4.2 by PKA has been shown to induce rapid internalization of the channel protein from the cell surface (Hoffman and Johnston, 1998, Kim et al., 2007, Lin et al., 2011)."
26456351
sparser
"Taken together these results suggest that distance-dependent Kv4.2 cycling is regulated by the phosphorylation of Kv4.2 by PKA."
21472817
reach
"These results indicate that PACAP/PAC1 signaling in hippocampal neurons could lead to dynamic phosphorylation of Kv4.2 protein, and PKA/ERK-dependent internalization of the channel protein from the cell surface."
26456351
sparser
"However, this same layer is highlighted by antibodies that recognize Kv4.2 that has been phosphorylated by PKA at the amino terminus."
11040264
sparser
"Kv4.2 phosphorylation by PKA at T38 and S552 residues, and S552 phosphorylation upon PKA pharmacological activation has been shown in hippocampal slices [ xref ]."
20600597
sparser
"Similarly, of the three antibodies tested, the soma of CA3 neurons are primarily recognized by the ERK triply phosphorylated Kv4.2 antibody, and the mossy fiber inputs to CA3 are primarily recognized by the carboxy-terminal PKA-phosphorylated Kv4.2."
11040264
sparser
"In addition, there is substantial evidence supporting the role of kinase regulation of A-type potassium currents in neurons, demonstrating a direct phosphorylation of the Kv4.2 channel subunit by PKA [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19596445
sparser
"The mechanism underling this effect requires PKA-dependent phosphorylation and downregulation of Kv4.2 channels, the molecular determinant of A-type K + currents."
35343587
sparser
"This activity-dependent increase in Kv4.2 cycling at distal dendrites was blocked by expression of Kv4.2gS552A. These results indicate that distance-dependent Kv4.2 mobility is regulated by activity-dependent phosphorylation of Kv4.2 by PKA."
21472817
sparser
"Although these data do not exclude the possibility that PKA phosphorylation of Kv4.2 disrupts associations with other scaffolding proteins, they suggest that Kv4.2 remains bound to PSD-95 after forskolin-induced internalization."
18650329
sparser
"The phosphorylation of Kv4.2 by protein kinase A (PKA), protein kinase C (PKC), and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) downregulates I A [ xref , xref , xref ]."
32824677
reach
"Kv4.2 phosphorylation by PKA drives Kv4.2 - KChIP2 dissociation, leading to Kv4.2 out of lipid rafts and internalization."
35508186
sparser
"Kv4.2 phosphorylation by PKA drives Kv4.2 - KChIP2 dissociation, leading to Kv4.2 out of lipid rafts and internalization."
35508186
sparser
"These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a."
20045463
reach
"However, the phospho-disruptive mutant Kv4.2-S552A channel exhibits PACAP38-induced reduction of current density similar to that observed in WT channels, suggesting no direct phosphorylation of Kv4.2 by PKA downstream of PACAP/PAC1 activation."
26456351
sparser
"Direct phosphorylation of Kv4.2 (at Ser 355) by PKA, however, has also been shown to decrease I A densities in hippocampal neurons ( xref )."
24106264