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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 phosphorylated on S15 increases the amount of CDKN1A. 2 / 2

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"Elevations in p53 expression and p53 Ser15 phosphorylation enhance p53 transcriptional activity, resulting in increased MKP-1 and p21 levels, and increased gene expression of Wip1, p21, and Cdkn2d (Cdk4 inhibitor)."

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"Phosphorylation of p53 on S15 by ATM and ATR and/or on S20 by CHK1 and CHK2 stabilizes p53 protein XREF_BIBR - XREF_BIBR and up-regulates the expression of p21 (also known as CIP1 and WAF1), an inhibitor of cyclin E/cyclin dependent kinase 2 (CDK2) that controls G1/S progression."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...