IndraLab

Statements

TP53 phosphorylated on S15 increases the amount of CDKN1A. 3 / 3
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"Elevations in p53 expression and p53 Ser15 phosphorylation enhance p53 transcriptional activity, resulting in increased MKP-1 and p21 levels, and increased gene expression of Wip1, p21, and Cdkn2d (Cdk4 inhibitor)."
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"For instance, p53 phosphorylation on Ser15 leads to p21 transcriptional expression and cell cycle arrest, while its phosphorylation on Ser46 leads to PUMA induction and apoptosis [ 75 ]."
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"Phosphorylation of p53 on S15 by ATM and ATR and/or on S20 by CHK1 and CHK2 stabilizes p53 protein XREF_BIBR - XREF_BIBR and up-regulates the expression of p21 (also known as CIP1 and WAF1), an inhibitor of cyclin E/cyclin dependent kinase 2 (CDK2) that controls G1/S progression."
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