A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TP53 phosphorylated on S15 increases the amount of CDKN1A. 2 / 2
| 2
reach
"Phosphorylation of p53 on S15 by ATM and ATR and/or on S20 by CHK1 and CHK2 stabilizes p53 protein XREF_BIBR - XREF_BIBR and up-regulates the expression of p21 (also known as CIP1 and WAF1), an inhibitor of cyclin E/cyclin dependent kinase 2 (CDK2) that controls G1/S progression."
reach
"Elevations in p53 expression and p53 Ser15 phosphorylation enhance p53 transcriptional activity, resulting in increased MKP-1 and p21 levels, and increased gene expression of Wip1, p21, and Cdkn2d (Cdk4 inhibitor)."