IndraLab

Statements

STAT3 activates COPS5. 7 / 7
| 7
reach
"Stat3 induced Jab1 transcriptional activation and protein expression."
21689417
reach
"Our findings that Stat3 positively regulates Jab1 and that Stat3 depletion sensitizes NPC cells to cisplatin suggest that assessing Stat3 and Jab1 levels in NPC patients will help predict the response of their disease to cisplatin treatment and enable the design of individualized treatment strategies for these patients."
27524414
reach
"Taken together, these data suggest that C/EBP-beta 2 and Stat3 bind to the Jab1 promoter to increase Jab1 promoter activities."
21689417
reach
"Stat3 Induced Jab1 Transcriptional Activation and Protein Expression."
27524414
reach
"In addition, transfecting NPC cell lines with ectopic Stat3 significantly increased both the protein and RNA levels of Jab1, and inhibition of endogenous Stat3 expression with specific short interfering RNAs (siRNAs) substantially decreased Jab1 levels and inhibited cell proliferation, indicating that Stat3 positively regulates Jab1 in NPC."
27524414
reach
"Second, our recent studies showed that Jab1 and CSN5 is transcriptionally activated by the Stat3 signaling pathway in breast cancer [XREF_BIBR], and in a similar case, our unpublished data seem to indicate that Stat3 positively regulates Jab1 and CSN5 in NPC."
22867945
reach
"Stat3 alone increased Jab1 promoter activity, but Stat3 along with C/EBP-alpha and C/EBP-beta synergistically increased Jab1 promoter activity, suggesting that Stat3 interacts with C/EBP on the Jab1 promoter."
21689417