IndraLab

Statements

USP25 inhibits NFkappaB. 10 / 11
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"The deubiquitinases (DUBs) A20 and USP25 negatively regulate IL-17-induced NF-kappaB and MAPK activation by removing ubiquitin modifications on TRAF6."
26320658
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"The analysis suggested that reconstitution of USP25 almost completely inhibited IL-17-induced activation of NF-kappaB compared to USP25 (C178S) (0.89 v.s 1.8 at 15 min, 0.61 v.s. 8.3 at 30 min, respectively) (XREF_FIG)."
23042150
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"Because USP25 negatively regulates IL-17-induced activation of NF-kappaB and stabilization of chemokine mRNA, which involves TRAF6 and TRAF5, respectively 26, we examined whether USP25 interacts with these TRAF proteins."
23042150
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"USP21 inhibits NF-kB activation through the deubiquitylation of RIPK1 [XREF_BIBR]."
25972356
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"To better understand the effects of USP25 in SEV induced type I IFN signaling, we assessed whether expression of USP25 disrupts SEV induced activation of IRF3 and NF-kappaB, the two important transcriptional factors in type I IFN signaling."
24260525
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"Because IFN-beta reporter activity is dependent on both NF-kappaB and IRF3, we further tested the inhibitory effect of USP21 on SeV-, RIG-I-CARD-, and TBK1 induced NF-kappaB and ISRE reporter activities."
24493797
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"We observed that overexpression of USP25 significantly inhibited SEV induced activation of IRF3 and NF-kappaB (XREF_FIG)."
24260525
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"USP21 was reported to target RIPK1 and inhibit NF-kappaB activity 96, however mice lacking USP21 show no defect in NF-kappaB signalling 93."
26503766
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"Interestingly, we found that overexpression of USP21 WT but not C221A mutant inhibited IFN-beta, NF-kappaB, and ISRE reporter activities in HEK293T cells in response to transfected poly (I : C), which was known to be mediated by MDA5 (unpublished data), suggesting that USP21 might also target MDA5."
24493797
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"The results showed that USP25-WT remarkably inhibited SEV induced activation of IFN-beta (XREF_FIG), IRF3 (XREF_FIG), NF-kappaB (XREF_FIG) and ISRE (XREF_FIG) in a dose dependent manner."
24260525