IndraLab

Statements

OTUB1 activates 4'-epidoxorubicin. 6 / 6
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"Overexpression of OTUB1, but not the OTUB1 (C91S) mutant, significantly enhanced the cell proliferation as well as the viability of WT MEFs in response to epirubicin (XREF_FIG)."
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"Our data show that WT OTUB1, but not the OTUB1 (C91S) catalytic dead mutant, can enhance the stability of FOXM1 in response to epirubicin in MCF-7 cells, suggesting that the deubiquitinase activity is required for the degradation of FOXM1."
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"In addition, proliferative and clonogenic assays also show that OTUB1 can enhance the proliferative rate and epirubicin resistance through targeting FOXM1, as OTUB1 has little effect on FOXM1 deficient cells."
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"Furthermore, we also found that OTUB1 overexpression enhanced the resistance of MCF-7 cells to epirubicin (XREF_SUPPLEMENTARY)."
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"OTUB1 promotes cell proliferation and epirubicin resistance through targeting FOXM1."
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"18 In here, we not only show that the potent oncogene FOXM1 is a target of OTUB1 but also present evidence to demonstrate that the oncogenic and genotoxic functions of OTUB1 depend on the expression of a functional FOXM1, suggesting that OTUB1 promotes cell proliferation and epirubicin resistance predominantly through targeting FOXM1."
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