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USP4 deubiquitinates HAS2. 3 / 3
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"USP17 efficiently removed polyubiquitination, whereas <span class="match term0">USP4</span> preferentially removed monoubiquitination of 6myc-<span class="match term1">HAS2</span>.;The deubiquitinating enzymes <span class="match term0">USP4</span> and USP17 target hyaluronan synthase 2 and differentially affect its function;USP17 and <span class="match term0">USP4</span> differently affect <span class="match term1">HAS2</span> ubiquitination, and the stability and function of <span class="match term1">HAS2</span>"
28604766
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"The de-ubiquitinase USP17 preferentially deconjugated polyubiquitin chains from HAS2, whereas USP4 significantly reduced the monoubiquitination of HAS2; thus, the two DUBs were found to selectively affect the activity and stability of HAS2."
28604766
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"For example, USP4 targets and deubiquitinates hyaluronan synthase 2 (HAS2), but USP4 does not maintain the stability of HAS, and, rather, loss of USP4 increases hyaluronan synthesis [33]."
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