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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MTOR phosphorylates AKT1 on threonine. 2 / 2

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"This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser (473), mTOR on Ser (2448), ribosomal protein S6 kinase on Thr (389), and eukaryotic initiation factor eIF4E binding protein on Thr (37)."

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"PI3-kinase (PI3K) is a signaling complex that phosphorylates phosphoinositides, regulating receptor trafficking and function at the membrane and translating cell surface signals into the phosphorylation of Protein kinase B (also termed Akt) and the serine-threonine protein kinase mammalian target of rapamycin (mTor)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...