IndraLab

Statements

SJB inhibits USP1. 7 / 7
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"USP1 inhibitor SJB selectively blocks USP1 enzymatic activity without blocking other DUBs."
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"In vitro assays using purified rDUBs showed that SJB inhibits USP1 (> 90% inhibition at 1muM) (XREF_FIG)."
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"SJB blocked cellular USP1 activity in a concentration dependent manner, without markedly affecting activity of other DUBs (USP2, USP7, USP14) (XREF_FIG, bar graph)."
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"We utilized a pharmacological inhibitor of USP1 SJB3-019A (SJB) that targets USP1 30."
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"Together, these data suggest that SJB is a specific inhibitor of USP1."
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"SJB induces the morphological differentiation and maturation of MM cells by blocking USP1 associated downstream signaling via ID proteins."
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"As shown in XREF_FIG, USP1 inhibition by SJB led to an increase in Ub-FANCD2, Ub-FANCI, and Ub-PCNA levels (XREF_FIG)."
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