IndraLab

Statements

CCND1 binds CDK4 and RB1. 10 / 10
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"Interestingly, the interaction between Rb and E2F1 was strongly detected in the absence of galectin-3, although Rb did not interact with cyclin D1 and CDK4 ( xref )."
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"It may be that 8q affects the formation of CDK4 and cyclin D1 complexes, which is the key step to regulate Rb [ xref , xref ]."
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"TNC regulates the cyclin D1-CDK4 complex formation and activity of Rb through regulation of FOXO1/β-catenin/p27 Kip1 ."
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"To investigate the requirement for p53 and Rb activity in senescence-associated OPN regulation, we ectopically expressed a well-characterized dominant negative p53 cDNA (p53-DD) ( xref ) or a cDNA expressing a fusion protein consisting of a mutant form of cyclin dependent kinase 4 R24C (Cdk4) and cyclin D1 (DK) that inhibits Rb ( xref ) ( xref )."
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"CyclinD1 binds and activates cyclin-dependent kinase CDK4 to phosphorylate inhibitory protein Rb protein in Gl phase [ xref , xref ]."
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"Upregulation of cyclin D1 in HNSCC cell lines is specifically associated with resistance to gefitinib by hyperphosphorylation of retinoblastoma protein (pRb) by cyclin D1-cyclin dependent kinase 4 (CDK4) ( xref )."
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"The results in Fig. xref C indicate that the ectopic expression of TNC enhanced the formation of the cyclin D1-CDK4 complex and Rb phosphorylation."
30519351
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"In fact, the proline-rich N-terminal portion of INSM1 has recently been shown to specifically bind cyclin D1, a key cell cycle regulator, and that through this interaction, INSM1 interrupts the interaction between cyclin D1 and cyclin-dependent kinase 4 (CDK4), which subsequently inhibits Rb phosphorylation [ xref ]."
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"To better understand the mechanism that TNC promotes the formation of the cyclin D1-CDK4 complex and Rb phosphorylation, we performed an immunoprecipitation assay using anti-CDK4 followed by a western blot with anti-cyclin D1."
30519351
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"2,3,7,8 tetrachlorodibenzo- p -dioxin (TCDD) is a lipophilic toxicant that inhibits estrogen signaling and disrupts interactions between CCND1, CDK4, and RB1 ( xref , xref )."
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