IndraLab

Statements

BAP1 inhibits metabolic process. 4 / 4
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"Diminished Pgc1alpha signaling likely contributes to some of the observed phenotypes in Bap1ko mice, but Bap1 likely modulates metabolism by additional means."
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"This resulted in a reduced list revealing that BAP1-downregulated genes were enriched in cell metabolism-associated genes."
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"Moreover, BAP1 deficiency drives the reprogramming of cell metabolism, promoting anaerobic glycolysis for energy production rather than mitochondrial respiration and increasing extracellular lactate secretion which induces immune evasion, tumour growth and cell malignant transformation.BAP1 emerges as a highly tissue-specific and context-specific tumour suppressor participating to the biology of the tumour with multiple mechanisms and different levels (summary in Table 1)."
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"Gene ontology (GO) analysis of 354 BAP1 upregulated and 187 BAP1 downregulated genes revealed that, while BAP1 upregulated genes were enriched in diverse cellular processes (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY), the genes that were downregulated by BAP1 showed striking enrichment in metabolism related biological processes, among which " response to oxidative stress " was the most significantly enriched (XREF_FIG and XREF_SUPPLEMENTARY)."
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