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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP7 decreases the amount of Bre1. 1 / 1

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"However, we did not observe any changes in the cellular levels of Bre1 following USP7 knockdown suggesting that, most probably, Mdm2 is ubiquitylating histones and that the observed defects in DNA repair and chromatin accessibility following USP7 knockdown observed in our experiments is due to the reduction in the levels of Mdm2 through self ubiquitylation (XREF_FIG B)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...