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USP7 decreases the amount of Bre1. 1 / 1

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"However, we did not observe any changes in the cellular levels of Bre1 following USP7 knockdown suggesting that, most probably, Mdm2 is ubiquitylating histones and that the observed defects in DNA repair and chromatin accessibility following USP7 knockdown observed in our experiments is due to the reduction in the levels of Mdm2 through self ubiquitylation (XREF_FIG B)."

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IndraLab

Statements

USP7 decreases the amount of Bre1. 1 / 1

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