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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SMAD3 phosphorylated on S37 is transcriptionally inactive. 1 / 1

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"PKC phosphorylates Smad2 in vivo and in vitro at Ser47 and Ser110, and Smad3 at the analogous Ser37 and Ser70 (Yakymovych et al., 2001). Phosphorylation of Smad3 by PKC blocks DNA-binding and consequently transcriptional regulation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...