IndraLab

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FBXW7 activates USP28. 2 / 2
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"Furthermore, expression of dominant negative Fbw7 or Fbw7 targeting shRNAs enhanced proliferation of Usp28 +/- MEFs, suggesting that their proliferative defect is, at least in part, mediated by the ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"This result suggests that Usp28 preferentially stabilizes Fbw7 due to more efficient binding and is consistent with the idea that Fbw7 targets Usp28 to its substrates.We concluded that stabilization o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"