IndraLab

Statements

EGFR binds ERBB2 and ESR1. 6 / 6
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"It is well established that in ER-positive breast tumors, overexpression of EGFR and/or HER2 is associated with resistance to endocrine therapy ( xref - xref )."
20944147
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"It is now well established that in ER-positive primary breast cancers, overexpression of both EGFR and HER2 is associated with resistance to endocrine therapy ( xref – xref )."
20204298
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"The docked complexes involving ESR1-EGFR and Erbb2 shown in Figure xref , Figure xref and Figure xref revealed that ESR1-EGFR and ESR1-Erbb2 interactions are mutually exclusive because of shared binding sites of the interacting proteins, and hence EGFR and Erbb2 cannot bind to ESR1 at the same time (see additional files xref , xref , xref )."
21974810
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"For example, concomitant over-expressions of the genes ERα36, EGFR and HER2 were strongly associated with aggressive forms (e.g. lymph node metastasis and high staging) of papillary thyroid carcinoma[ xref ]."
29532246
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"We hypothesize that direct interaction of the HER tyrosine kinases with the ER leads to the ER activation and is involved in the compensatory targeted therapy resistance mechanisms."
28493933
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"Concomitant high expression of ERα36, EGFR and HER2 was strongly associated with aggressive behaviors including extrathyroidal extension (ETE), lymph node metastasis (LNM) and high TNM stage in PTCs (P < 0.001)."
28947799