IndraLab

Statements

ESR1 binds EGFR and ERBB2. 3 / 3
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"Concomitant high expression of ERα36, EGFR and HER2 was strongly associated with aggressive behaviors including extrathyroidal extension (ETE), lymph node metastasis (LNM) and high TNM stage in PTCs (P < 0.001)."
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"For example, concomitant over-expressions of the genes ERα36, EGFR and HER2 were strongly associated with aggressive forms (e.g. lymph node metastasis and high staging) of papillary thyroid carcinoma[ xref ]."
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"The docked complexes involving ESR1-EGFR and Erbb2 shown in Figure xref , Figure xref and Figure xref revealed that ESR1-EGFR and ESR1-Erbb2 interactions are mutually exclusive because of shared binding sites of the interacting proteins, and hence EGFR and Erbb2 cannot bind to ESR1 at the same time (see additional files xref , xref , xref )."
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