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CYLD decreases the amount of CYLD. 11 / 13
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"To determine whether higher PAI-1 expression in MEF cells from Cyld −/− mice is a developmental defect or simply results from loss of the inhibitory function of CYLD on PAI-1 expression, we next evalu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Western blotting and a dual-luciferase reporter assay were used to verify that miR-1288 targets CYLD by interacting with the 3 ' UTR of CYLD to reduce CYLD expression."
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"In vitro cell proliferation was measured and the result shows that CYLD knockout causes cell proliferation enhancement and CYLD overexpression causes cell proliferation suppression (XREF_FIG C, D)."
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"An adeno associated virus (AAV) vector encoding CYLD was used to suppress CYLD expression by being intratracheally instilled in rats 7 days before MCT-AV treatment."
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"Adenoviral over-expression of CYLD shRNA dose-dependently inhibited CYLD mRNA expression with an efficacy of> 90% knockdown of endogenous CYLD at dose of 10 multiplicity of infection (MOI) in HK-2 cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Adenoviral over-expression of CYLD shRNA (20 MOI) completely inhibited CYLD protein expression."
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"In trophozoite-treated cells, A20 and CYLD knockdown could impede the up-regulation of mRNA expressions of A20 ( p < 0.01) and CYLD ( p < 0.01), respectively, but not affect increased TNFR1 mRNA expre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, protein expression of SOX2 and EGFR was reduced while there was a greater increase in CYLD expression following treatment with sh-SOX2, while additional miR-222-5p agomir only decreased CYLD protein expression without affecting SOX2 and EGFR expression (Figure 7E, 7F)."
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"Further studies revealed that ectopic expression of ZNF333 resulted in decreased mRNA and protein levels of CYLD, whereas knockdown of ZNF333 increased CYLD levels (Figures 7D–7F)."
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"As CYLD and caspase-8 are constitutively expressed in the tested human cancer cells and IFNγ stimulation further increases their expression (Fig. 2), we use shRNAs for CASP8 and CYLD to decrease the expression levels of caspase-8 and CYLD upon IFNγ stimulation to achieve a comparable level as that in untreated control cells (Fig. 3, C and E, lanes 4 versus lanes 1)."
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"To further confirm CYLD as a target for human melanoma, specific si-RNAs of CYLD were used to inhibit CYLD expression in both melanoma cells A375 and WM35, respectively."
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