
IndraLab
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"Causative mutations are located in the SCN4A gene encoding the sodium channel Nav1.4 initiating the AP, the CACNA1S gene encoding the calcium channel Cav1.1 coupling the AP to contraction, or the KCNJ2 and KCNJ18 genes encoding the potassium channels Kir2.1 and Kir2.6 that maintain the resting potential."