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Sodium atom inhibits CACNA1A. 14 / 14
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"Pulmonary veins with dormant conduction show less radiofrequency-induced depolarization than non-dormant veins do, allowing for adenosine-induced hyperpolarization to restore excitability by removing voltage-dependent sodium current (I Na ) inactivation at less negative membrane potentials."
28765753
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"Thus, the specific abolition of voltage-dependent Na + current inactivation by intracellular treatment with proteolytic enzymes (Armstrong et al., xref ) subsequently led to the proposal of a “ball-and-chain” mechanism as the determinant of this inactivation process (Armstrong and Bezanilla, xref )."
22470342
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"The “switch-off” frequency was not due to voltage-dependent Na + channel inactivation because simulations were performed with HH parameters, limiting the inactivation of Na + channels (see the simulation methods for Na + channels)."
26912194
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"Resting cells would generate suprathreshold GABA A receptor-mediated depolarizing postsynaptic potentials, whereas spontaneously active cells would be driven into a refractory state due to voltage-dependent sodium channels inactivation ( xref )."
30071194
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"Cells where the inactivating, slowly deactivating current phenotype prevails feature a robust afterhyperpolarization that relieves voltage-dependent Na + channel inactivation and thus, promotes repetitive AP firing ( xref ; xref ; xref ; xref )."
22584144
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"The repetitive firing observed in skeletal muscle fibres in patients with paramyotonia congenita arises from an incomplete voltage-dependent Na + channel inactivation thus leaving some channels in a conductive state [ xref ]."
28265756
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"Deficits in sodium channel may contribute to these phenotypes since hippocampal neurons from BACE1-null mice display a positive shift in voltage-dependent sodium current inactivation as well as an increase in sodium current densities as compared to control wild-types [ xref , xref ]."
20817076
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"To explore the effects of IL-6 on other aspects of voltage-gated Na + channels, we analyzed and compared voltage-dependent Na + channel activation and inactivation at different doses and various time points."
26170823
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"MFN2-mutant motor neurons had an increased density of sodium currents in their membrane, and their voltage-dependent sodium channels demonstrated impaired inactivation after a use-dependent paradigm, compared to controls."
25448007
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"We have demonstrated that the “switch-off” frequency is not due to voltage-dependent Na + channel inactivation (see above)."
26912194
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"But at a fixed and elevated Na, some of the linearity of K Na activation over then range of -80 to -20 mV will arise from a combination of increased activation by voltage and also voltage-dependent inhibition by intracellular Na."
26559620
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"The finding that all α-cells (and some β-cells) exhibit biphasic voltage-dependent Na + current inactivation suggests that Na + channel subunits with widely different inactivation properties are coexpressed in individual cells."
25172946
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"The alpha2* isoform was, however, more sensitive to voltage-dependent inhibition by extracellular Na(+), indicating a higher affinity of the extracellular Na(+) site in this isoform."
11897839
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"Membrane hyperpolarization removes voltage-dependent Na + current inactivation, increases the source Na + current, and permits faster and more stable rotor activity."
19968926