IndraLab

Statements

USP8 increases the amount of EGFR. 12 / 12
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"Consistently, the expression of EGFR was decreased by genetic silencing of USP8."
30010158
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"Similar to Marks et al., we found an elevated EGFR expression in DU145 and PC3 which was severely increased upon USP8 overexpression and docetaxel treatment, whereas silencing USP8 significantly reduced EGFR expression and thereby decreased NF-kB signal activation."
36338727
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"Hotspot USP8 variants lead to persistent EGFR overexpression, thereby perpetuating the hyper-synthesis of ACTH."
37925320
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"In this study, we found that inhibiting USP8 reduced the expression of the EGFR protein in an ARID1A-deficient OCCC cell line."
40074856
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"Thereby, together with these data, it can be concluded that the elevated level of USP8 not only increases the expression of EGFR, PI3K, and P-Akt but also might increase the PI3K and P-Akt expression over EGFR silencing where the PI3K and P-Akt well established the downstream target of EGFR ( Figures 6C, D )."
36338727
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"USP8 is known to deubiquitinate EGFR in response to ligand stimulation. USP8 depletion accelerates receptor turnover, whereas loss of hepatocyte growth factor-regulated substrate (Hrs) rescues this phenotype, indicating that USP8 protects EGFR from degradation via an Hrs-dependent pathway. [..]As EGFR stabilization against lysosomal turnover requires deubiquitination by USP8."
20736164
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"Moreover, USP8 knockdown reduced EGFR protein level in USP8 mutated tumor cells (XREF_SUPPLEMENTARY)."
25675982
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"USP8 knockdown in primary ACTH secreting tumor cells, however, reduced ACTH secretion and EGFR levels, suggesting that inhibition of USP8 activity may be an effective treatment strategy for CD."
27569239
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"Western blotting confirmed that knockdown of USP8 not only reduced RTK phosphorylation, but also the total levels of EGFR, ERBB2, ERBB3, and MET in H1975 and H1650 cells (XREF_FIG)."
23748694
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"Taken together, our findings demonstrate for the first time that inhibition of USP8 down-regulates the total protein levels of EGFR, ERBB2, ERBB3, and MET, and effectively attenuates related RTK signaling pathways."
23748694
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"From the above discussion, it is clear that USP8 is an important deubiquitinase that most importantly could increase the expression of EGFR and NICD."
33600786
signor
"Here, we describe the role of a deubiquitinating enzyme UBPY/USP8 in the down-regulation of epidermal growth factor (EGF) receptor (EGFR). Overexpression of UBPY reduced the ubiquitination level of EGFR and delayed its degradation in EGF-stimulated cells."
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