IndraLab

Statements

IGF1R binds INSR and IRS1. 6 / 6
| 6
sparser
"Thus, IGFIR, IR and IRS-1 bind to hp55 γ in vitro and this binding requires receptor activation."
9524259
sparser
"As expected, stimulation of WT KCs with insulin or IGF-1 led to the association of IRS-1 with IR ( xref , 2 nd row, lanes 3 and 4, respectively) and IGF-1R ( xref , 5 th row, lanes 3 and 4, respectively)."
24326453
sparser
"Activated INSR and IGF1R interact with insulin receptor substrate 1 (IRS1) to activate an intracellular signaling network, including AKT, mTOR, and mitogen‐activated protein kinase 1 (ERK1)/2. xref , xref We then analyzed insulin‐IGF1 signaling in the hearts of CKO and control mice post‐TAC."
| PMC
sparser
"Interaction with proteins that have been reported to interact with insulin receptor and/or IGF-I receptor such as the docking proteins IRS-1, IRS-3 as well as the PI3 kinase regulatory subunit p85, th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15629149
sparser
"As an important mitogen, insulin may promote cancer progression through its binding to the insulin receptor (IR) and/or IGF-1R (insulin-like growth factor receptor), which results in auto-phosphorylation of insulin-receptor substrate-1 (IRS-1) and activation of the phosphatidylinositol 3-kinase (PI3K)/Akt (serine/threonine kinase)/mammalian target of rapamycin (mTOR) pathway and the mitogen-activated protein kinase (MAPK) pathway xref ."
27642100
sparser
"GM3S depletion increases the association of IR, IRS-1, and IGF-1R."
24326453