IndraLab

Statements

USP1 inhibits EZH2. 4 / 4
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"We find that overexpression of USP1 promotes EZH2-mediated repression of downstream tumor suppressor genes and GBM tumorigenesis, which thus expands our understanding of the functional mechanism of USP1 in tumorigenesis."
30425057
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"Moreover, elevated expression of EZH2 target genes triggered by knockdown of USP1 is abolished by overexpression of K421R/Y641F mutant of EZH2 which is resistant to degradation by the proteasome (Sahasrabuddhe et al., 2015; Yu et al., 2013)."
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"These results support that USP1 promotes EZH2-mediated gene repression by stabilizing EZH2."
30425057
reach
"USP1-mediated EZH2 stabilization represses downstream gene expression.."
30425057