IndraLab

Statements

USP10 activates AICDA. 5 / 5
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"h USP10 knockdown promoted AID degradation."
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"Collectively, we demonstrated that USP10 functions as an integrator for both BCR and TLR signals and directly regulates nuclear AID activity."
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"The relative fluorescence signal was calculated through fluorescence intensity at a certain time divided by fluorescence intensity at 0 h. i The USP10 overexpression inhibited AID degradation."
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"Collectively, these results indicated that BCR and TLR2 synergistically enhance Akt activity and promote USP10 T674 phosphorylation located within the NLS domain and, therefore, the nuclear import of USP10, consequently inhibiting the AID degradation in the nucleus.Pam 3 Csk 4 helped to enhance the antibody response to the SARS-CoV-2 RBD nanoparticle vaccine Pam 3 Csk 4 has been used as a vaccine adjuvant."
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"These results indicated that USP10 mainly inhibited AID degradation in the nucleus and affected the AID abundance in the cytoplasm.The concentration of nuclear AIDs is important."
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