IndraLab

Statements

AKT phosphorylates CDKN1B on threonine. 5 / 5
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reach
"The nuclear localisation signal of p27 contains an AKT consensus site at threonine 157, and phosphorylation of this threonine residue on p27 by AKT inhibits p27 's import to the nucleus."
25965299
sparser
"The nuclear localisation signal of p27 contains an AKT consensus site at threonine 157, and phosphorylation of this threonine residue on p27 by AKT inhibits p27's import to the nucleus."
25965299
trips
"Although Akt also phosphorylated p27(Kip1) at Ser(10) and Thr(187), these two sites were not involved in the binding to 14-3-3 proteins."
12042314
reach
"XREF_BIBR Akt directly phosphorylates p27 on multiple Threonine (T) residues, including T198, which have been shown to promote nuclear export and sequestration of p27 in the cytoplasm, resulting in the inactivation of the protein in human cells."
26997868
reach
"Although Akt also phosphorylated p27 (Kip1) at Ser (10) and Thr (187), these two sites were not involved in the binding to 14-3-3 proteins."
12042314