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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Quinolone deubiquitinates ZUP1. 1 / 1

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"Despite having similar molecular size and functionality, the diterpene quinolone tanshinone derivatives, 1-6, inhibit the SARS-CoV PL pro isomerization slow-binding mode, whereas the abietane type derivative, 7, is active against PL pro through the simple slow-binding mode.PL pro , located within nsp3, cleaves at nsp1/2, nsp2/3 and nsp3/4 boundaries using the consensus motif LXGG, along with a consensus cleavage sequence of cellular deubiquitinating (DUB) enzymes."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...