IndraLab

Statements

TP53 phosphorylated on T18 is transcriptionally active. 4 / 4
2 2 |
bel
"Endogenous p53 is also phosphorylated in Thr18 by VRK2B, promoting its stabilization and transcriptional activation in A549 cells"
16704422
bel
"Endogenous p53 is also phosphorylated in Thr18 by VRK2B, promoting its stabilization and transcriptional activation in A549 cells"
16704422
bel
"Thr18 residue phosphorylation, in the transactivation domain of p53, has been implicated in both disruption of p53-Mdm2 interaction and p300 coactivator recruitment, which acetylates the p53 carboxy terminus. This leads to a decrease in p53 degradation and its subsequent stabilization and to an increase in p53-dependent transactivation activity."
15542844
bel
"Thr18 residue phosphorylation, in the transactivation domain of p53, has been implicated in both disruption of p53-Mdm2 interaction and p300 coactivator recruitment, which acetylates the p53 carboxy terminus. This leads to a decrease in p53 degradation and its subsequent stabilization and to an increase in p53-dependent transactivation activity. "
15542844