IndraLab

Statements

USP18 activates transport. 5 / 5
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"Warsi, et al demonstrated that transport activity of rabbit peptide transporters Pept1 and Pept2 was decreased in Xenopus laevis oocytes injected with cRNA encoding the E3 ubiquitin ligase Nedd4-2, whereas overexpression of USP18 (Ubiquitin like specific protease 18), an enzyme cleaving ubiquitin from target proteins, stimulated the transport activity of rbPept1 and rbPept2 [XREF_BIBR]."
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"XREF_BIBR, XREF_BIBR A recent study found that USP18 can enhance the cellular transport rate in Xenopus laevis oocytes by increasing the activity of PEPT1 and PEPT2; this activation was believed to be due to the reversal of ubiquitination and the subsequent degradation of carrier protein."
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"Accordingly, USP18 apparently enhances the maximal transport rate."
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"16, 23 A recent study found that USP18 can enhance the cellular transport rate in Xenopus laevis oocytes by increasing the activity of PEPT1 and PEPT2; this activation was believed to be due to the reversal of ubiquitination and the subsequent degradation of carrier protein."
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"53 In addition to ISG15, USP18 also specifically inhibits K63-linked ubiquitination of NEMO, leading to the negative regulation of NF-κB activation induced by the TAK1-TAB complex.16, 23 A recent study found that USP18 can enhance the cellular transport rate in Xenopus laevis oocytes by increasing the activity of PEPT1 and PEPT2; this activation was believed to be due to the reversal of ubiquitination and the subsequent degradation of carrier protein.54The innate immune system reduces viral replication via IFN-I; this reduction is essential for inhibiting the spread of virus to other organs."
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