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Statements

USP18 activates transport. 3 / 3
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"Warsi, et al demonstrated that transport activity of rabbit peptide transporters Pept1 and Pept2 was decreased in Xenopus laevis oocytes injected with cRNA encoding the E3 ubiquitin ligase Nedd4-2, whereas overexpression of USP18 (Ubiquitin like specific protease 18), an enzyme cleaving ubiquitin from target proteins, stimulated the transport activity of rbPept1 and rbPept2 [XREF_BIBR]."
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"XREF_BIBR, XREF_BIBR A recent study found that USP18 can enhance the cellular transport rate in Xenopus laevis oocytes by increasing the activity of PEPT1 and PEPT2; this activation was believed to be due to the reversal of ubiquitination and the subsequent degradation of carrier protein."
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"Accordingly, USP18 apparently enhances the maximal transport rate."
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