IndraLab

Statements

PRMT5 methylates TP53 on R337. 4 / 4
| 2 2
sparser
"PRMT5 methylates p53 at R333, R335, and R337, resulting in changes in oligomerization, nuclear location, and DNA binding specificity. xref Moreover, DNA damage led to elevated p53 dimethylation."
34314149
reach
"The PRMT5 dependent methylation of p53 at residues R333, R335 and R337 represses the p53-DNA interaction."
32379587
sparser
"Additionally, PRMT5 may directly methylate P53 on R333, R335 and R337, preventing its oligomerization with MDM2, which prevents TP53 binding to its target genes xref ."
36167829
reach
"In particular, PRMT5 interacts with and methylates p53 at R333, R335 and R337 upon DNA damage (XREF_FIG)."
21975038