IndraLab

Statements

Phosphorylated MTOR phosphorylates RPS6KB1. 13 / 13
| 12 1
reach
"We reported that IPostC increases phosphorylated Akt (p-Akt), phosphorylated mTOR (p-mTOR), phosphorylated S6K (p-S6K), and phosphorylated 4EBP1 (p-4EBP1) in the mTOR pathway and increases the presynaptic growth associated protein 43 (GAP43) protein levels (Xie et al., 2013)."
34396060
reach
"We reported that IPostC increases phosphorylated Akt (p-Akt), phosphorylated mTOR (p-mTOR), phosphorylated S6K (p-S6K), and phosphorylated 4EBP1 (p-4EBP1) in the mTOR pathway and increases the presynaptic growth associated protein 43 (GAP43) protein levels (Xie et al., 2013)."
34396060
reach
"Thus, Western blotting analysis was conducted, and we found increased levels of phosphorylated mTOR (p-mTOR), phosphorylated S6K (p-S6K), and phosphorylated S6 (p-S6) in the Opalin cKO mice compared with the control mice (SI Appendix, Fig. S3 A and B)."
39083419
reach
"In mTOR-dependent autophagy, phosphorylation of mTOR leads to ribosomal P70S6K1 phosphorylation, preventing initiation of autophagy [ 45 ]."
34662652
reach
"MTOR phosphorylation activates protein synthesis by phosphorylating 70 kDa ribosomal protein S6 kinase (p70S6K), which is downstream of the mTOR pathway (Mascher et al., 2011; Wang et al., 2001)."
38898369
reach
"Thus, Western blotting analysis was conducted, and we found increased levels of phosphorylated mTOR (p-mTOR), phosphorylated S6K (p-S6K), and phosphorylated S6 (p-S6) in the Opalin cKO mice compared with the control mice (SI Appendix, Fig. S3 A and B)."
39083419
reach
"Because of the apparently discordant results noted above related to mTOR kinase activation (e.g., no change in mTOR and 4E-BP1 phosphorylation, but increased S6K1 phosphorylation), we also assessed key up-stream regulators of mTOR activity."
27464336
reach
"Then, the phosphorylation of mTOR and the increase in MgATP 2− raise the phosphorylation of p70S6K and 4EBP1, which increases the frequency of initiation of protein synthesis [ 35 ]."
33592327
reach
"Critical components in the translational machinery, such as phosphorylated mammalian target of rapamycin (mTOR) and its downstream targets, phosphorylated eukaryotic translation initiation factor and p70 S6 kinase, were up-regulated following NO treatment, and inhibition of mTOR with rapamycin attenuated NO induced increase of cyclin D1 and ODC."
17210710
sparser
"In general, p-mTOR induces phosphorylation of 4E-BP1 and P70S6K, and initiation of translation and protein synthesis."
28005970
reach
"The p-mTOR activates p70S6K, and phosphorylated p70S6K combines with translation initiation complexes, to improve the efficiency of mRNA translation [XREF_BIBR]."
28005970
reach
"MTOR phosphorylation led to the phosphorylation of p70S6K, mTOR dependent event, that was abrogated by the mTOR specific inhibitor rapamycin."
26053099
reach
"In the downstream mTOR signaling pathways, p-mTOR can improve the translation efficiency of 5 '-TOR mRNA and accelerate protein synthesis by phosphorylating its downstream receptors during the translation process, such as elF4E and p70S6 kinase [XREF_BIBR]."
27835987