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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNMA1 inhibits beta1 subunit. 2 / 2

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"Mutations in the Slo1 VSD that alter VSD activation and reduce the beta1 subunit modulation of Ca 2+ sensitivity have little impact on the beta2 subunit modulation of Ca 2+ sensitivity."

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"Mutations in the Slo1 VSD that alter VSD activation have been shown to reduce the effect of the beta1 subunit on Ca 2+ sensitivity; interestingly, the degree to which a mutation alters voltage-sensor activation is inversely correlated with the magnitude of the beta1 subunit 's effects on Ca 2+ sensitivity of the mutant channel."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...