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AKT increases the amount of SERPINE1. 10 / 11
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"These findings indicate that p38- and PKB dependent signalling pathways contribute to enhanced PAI-1 levels in the hypoxic response."
12669121
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"Another study showed that over-expression of PAI-1 accelerated head and neck cancer cell migration by the activation of the PI3K and AKT pathway [XREF_BIBR]."
| PMC
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"24 h after transfected with siRNA, the cells were treated with AKT inhibitor miltefosine (5 μM) for another 48 h. Western blot showed that inhibition of AKT attenuated SERPINE1 expression induced by ELK3 silencing (Figure 4(c)), suggesting that activation of AKT pathway may be one of the reasons for upregulation of SERPINE1 after ELK3 knockdown."
32104682
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"Indeed, direct activation of Akt by expressing a constitutively active form of C/A-Akt induces expression of fibrotic response gene PAI-1 and CTGF in Smad3 +/+ cells, but not in Smad3 -/- cells (XREF_SUPPLEMENTARY)."
22491319
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"Expression of PAI-1, moreover, is both induced and regulated by the PI3K/AKT network [210, 211] , and increased PAI-1 levels activate the PI3K/AKT survival pathway [212] ."
35267539
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"As shown in XREF_SUPPLEMENTARY, activation of Akt by expressing a constitutively active C/A-Akt indeed induced expression of PAI-1 and CTGF in Smad3 +/+ cells, but not in Smad3 -/- cells."
22491319
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"Inhibition of the PI3K and Akt pathway abrogates TGF-beta-induced PAI-1 expression by disrupting the TGF-beta-induced interaction of transcriptional coactivator and acetyltransferase CBP with activated Smad3."
21465481
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"An expanded analysis of the murine fibrosarcoma cells discussed above revealed that PAI-1 deficient fibrosarcomas have reduced Akt signaling and reintroduction of PAI-1 expression in deficient cells results in an increase in Akt signaling [XREF_BIBR]."
20079523
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"In contrast, constitutively active PI 3 kinase and Akt kinase increased PAI-1 expression, similar to TGFbeta."
17671970
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"Furthermore, the administration of Akt activity inhibitors greatly diminished the expression of NF-kappaB and PAI-1."
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