IndraLab

Statements

PCNA activates USP1. 6 / 6
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"Our results indicate PCNA posttranslational modifications and regulation mediate USP1 dependency."
36228090
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"In addition, the L1 insert of USP1 has been shown to be critical for specific substrate-mediated activation of USP1 by DNA-loaded PCNA ( Dharadhar et al., 2021 )."
34813758
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"Usp1 modulates DNA replication, polymerase choice and DNA repair by PCNA and as a result Usp1 knock-out mice are genetically unstable and hypersensitive to DNA damage [XREF_BIBR], [XREF_BIBR]."
25962961
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"Similar results have been seen in the case of Usp1 and Uaf -1 where knockdown of either protein alone altered the ubiquitination status of Usp1 targets PCNA and FANCD2, in this example an epistatic relationship between Usp1 and Uaf-1 was observed [XREF_BIBR]."
26462181
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"PCNA ubiquitination and protein loss mediate USP1 dependency."
36228090
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"Because PCNA ubiquitination mediates USP1 dependency, we evaluated the effect of USP1–PARP inhibitor combination on PCNA posttranslational modifications."
36228090