IndraLab

Statements

PCNA activates USP1. 3 / 3
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"Usp1 modulates DNA replication, polymerase choice and DNA repair by PCNA and as a result Usp1 knock-out mice are genetically unstable and hypersensitive to DNA damage [XREF_BIBR], [XREF_BIBR]."
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"Similar results have been seen in the case of Usp1 and Uaf -1 where knockdown of either protein alone altered the ubiquitination status of Usp1 targets PCNA and FANCD2, in this example an epistatic relationship between Usp1 and Uaf-1 was observed [XREF_BIBR]."
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"However, pathway (s) responsible for the regulation of USP1 as well as the molecular mechanism by which USP1 regulates DDR in beta-cells, especially in the diabetic environment, remains unknown and wa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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