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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RAF1 phosphorylates MAP2K1 on serine. 3 / 3

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reach

"Raf-1 phosphorylates MEK1 on two serine residues, Ser 218 and Ser222 [XREF_BIBR] MEK1 phosphorylates tyrosine and threonine residues in the ERK activation loop."

23728975

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rlimsp

"Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation."

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sparser

"After activation of EGFR signaling, key downstream steps involve phosphorylation by RAF1 kinase of two distinct serine residues on both MEK1 and MEK2 ( xref )."

18632602

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...