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Statements

CYLD inhibits RELA. 6 / 6
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"In the search for the tumor suppressor function of CYLD, several laboratories reported that CYLD can inhibit the activation of the classical NF-kappaB p65 and p50 transcription factor (Trompouki et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, transfection of p65 alone or in combination with p50 increased the 3XkappaB luciferase reporter activity to a similar extent in Cyld +/+ and Cyld -/- keratinocytes, confirming that Cyld nega[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Based on these data, we conclude that loss of Cyld in keratinocytes does not promote the activity of the p65 and p50 NF-kappaB but rather promotes the synergistic activation of p50 and Bcl -3 or p52/B[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD reduced activation of p65, JAK2, STAT3, and p38 MAPK as well as fibrin production in livers of Listeria infected WT mice."
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"To explore the correlation between the ZNF333/CYLD axis and NF-κB pathway, we conducted an immunofluorescence assay and confirmed that elevated levels of CYLD significantly inhibited the nuclear translocation of p65 upon stimulation with tumor necrosis factor α (TNF-α) (Figure S5E)."
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"In vitro studies have suggested that CYLD negatively regulates the p65/p50 NF-κB pathway by removing K63-linked polyubiquitin chains from TRAF2/6 ( Brummelkamp et al., 2003; Kovalenko et al., 2003; Ma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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